Euroscreen Extends Its Patent Estate for CCR5 Chemokine Receptor and AIDS
Euroscreen s.a., a world leader in G-protein-coupled receptors (GPCRs), today announced the issue of a key European patent (0 883 687B1) in the area of HIV infection. The patent claims screening methods using the human CCR5 receptor to single out compounds as well as antibodies which can be used in the treatment and/or prevention of HIV infection. Such antibodies are also protected by claims section.The CCR5 receptor plays a central role in the mechanism by which human immunodeficiency virus (HIV) binds to and enters white blood cells, and therefore represents a key target in the search for effective novel treatments for HIV infection and AIDS.
Antibody therapy is one potential approach to blocking HIV entry as an AIDS therapy. Pursuant to an agreement dated January 2003, Euroscreen and ICOS combined their respective patent estate with regards to CCR5 technology.
This combination built a comprehensive patent portfolio for CCR5 which enables Euroscreen to offer the rights to companies who are developing therapeutic drugs as well as antibodies that modulate the CCR5 receptor.Commenting on the announcement, Dr Pierre Nokin, Euroscreen President and CEO said: "In 2004 we have both strengthened and extended our portfolio with regards to CCR5, a popular target included in the pipeline of several big pharma and biotech companies for its crucial role as HIV co-receptor. Together with ICOS, our combined portfolio covers both the relevant aspect of the CCR5 technology and the major areas in which innovative research is done. This first European patent award is a significant milestone in the development of Euroscreen, as it represents and justifies many years of outstanding work performed by Prof. Marc Parmentier (CSO of Euroscreen) and his scientific team."The CCR5 receptor and its role in various diseases The CCR5 receptor belongs to a family of cell membrane proteins called G protein-coupled receptors (GPCRs). Specifically, CCR5 is found on the surface of T cells (white blood cells), which form part of the human immune system.
The protein consists of 352 amino acids and spans the T-cell membrane seven times. Under normal circumstances, CCR5 binds certain proteins known as chemokines, which act as chemical attractants recruiting immune cells to sites of inflammation. CCR5 is considered as a drug target in the field of HIV, but also in a growing number of inflammatory diseases. The potential of CCR5 as a key target for several therapies is very promising due to the significant safety profile already seen for both small molecule and antibody drug candidates presently in human clinical trials for HIV from a number of companies and will soon also enter clinical trials for the treatment of other disorders such as Graft rejection, multiple sclerosis or rheumatoid arthritis.For further information, please contact:Euroscreen s.a.???Tel: +32 71 348 500??????email: e-mail protected from spam botsPierre Nokin, Ph.D.President and CEO Vincent Lannoy, Ph.D.Intellectual Property ManagerAbout Euroscreen SAEuroscreen is a world leader in G-protein coupled receptors (GPCRs). The Company integrates its research expertise in this area with its patented high-throughput AequoScreen? cellular assay platform to patent new GPCR targets and drug candidates.The Company is building its own patent portfolio of GPCR targets and novel drug leads for licensing to biopharmaceutical companies, and to date has agreements with, CyBio, EvotecOAI, Galapagos Genomics, GE Healthcare, ICOS, Merck & Co, Pfizer Inc, Solvay, Syngenta and UCB.
Euroscreen has also established collaborations with numerous academic centers for access to licenses to help in making available its broad menu of GPCR-based products (recombinant cell lines and membrane preparations) and services (custom screening and cloning). Euroscreen has grown significant and strong patent positions to protect many key drug targets for licensing. Such patents include CCR5, GnRH-R strongly involved in hormonal diseases and prostate cancer, GPR7/8 involved in metabolic defects and adult-onset obesity, purinergic receptors (P2Y4, P2Y11 and P2Y13) and the non-GPCR SHIP2 for type II diabetes. Euroscreen is able to offer rights to companies which are developing therapeutic drugs that act through the above-mentioned key targets mode of action. For more information regarding the Euroscreen's portfolio, please contact Dr.
Vincent Lannoy.Euroscreen is a privately held company based in Brussels, Belgium with 80 employees of which 50 are in R&D.More information can be found at www.euroscreen.be.
Cincinnati Cancer Clinic and Dr. Martin Weinstock Joining Forces to Promote Breast Health
Cincinnati, Ohio (ContentDesk) December 18, 2005 -- Cincinnati Cancer Clinic and Dr. Martin Weinstock hopes to bring awareness and assistance to women from the Cincinnati area through a new breast education, treatment, and screening program he has instituted at the Cincinnati Cancer Clinics Pennington Education Center. The Center is at the Cincinnati Junior College School facility dedicated to the promotion of literacy for adults and teens and serves approximately 3,200 students each year."Breast Cancer is an anxiety-provoking topic for many women, and understanding what you can do to detect and arrest breast cancer is important to all women," says Dr. Weinstock, breast cancer health specialist at the Cincinnati Clinic. "We hope to be able to help the women in our community who are not accessing health care to understand the importance of screening for breast cancer, and then actually get them screened."In a program that started in early October, Dr.
Weinstock and several colleagues...
Cincinnati Cancer Clinic and Dr. Martin Weinstock Joining Forces to Promote Breast Health
Hearing aids > Cincinnati Cancer Clinic and Dr. Martin Weinstock Joining Forces to Promote Breast Health
Baseball Almanac Releases Opening Day Section that Provides Comprehensive Statistics for All Baseball Teams
With baseball season just around the corner, let baseball-almanac.com get you geared up for the first game of the year with its new section devoted entirely to Opening Day!
Baseball Almanac has the complete list of Opening Day scores for all 30 MLB teams, box scores for every Opening Day game from 1969 to 2003, and an assortment of facts about Opening Day that you can't find anywhere else [http://www.baseball-almanac.com/opening_day/opening_day.shtml.
Whether you're looking for the pitcher who threw an shutout for the Cleveland Indians in the 1988 opener (Scott Bailes), or wondering which team has the best winning percentage on Opening Day (Toronto Blue Jays, .750), you'll find the answers to those questions and many others on baseball-almanac.com.With over 110,000 pages, Baseball Almanac manages to be a valuable tool for researchers while still remaining incredibly accessible.
Hearing aids > Baseball Almanac Releases Opening Day Section that Provides Comprehensive Statistics for All Baseball Teams
Next Step Foundation files federal lawshuit against Stowe Township - Cites discrimination against recovering alcoholics and addicts
Next Step Foundation, a non-profit organization dedicated to providing transitional housing, education and support to people in recovery from drug and alcohol addiction has filed a federal lawsuit today against Stowe Township for discrimination against operating a recovery house at its property at 936 Broadway Avenue in Stowe Township.
The complaint, which includes a temporary restraining order and preliminary injunction, was filed this morning in the United States District Court for the Western District of Pennsylvania.
THERE WILL BE A HEARING IN FEDERAL COURT TOMORROW AUGUST 26, 2004 AT 9:00AM concerning the complaint in front of Judge Hardiman, 829 US Courthouse, 7th and Grant Street, Pittsburgh, PA.
Next Step Foundation, directed by David and Lynne Francis, has attempted, without success, to obtain an occupancy permit for its property that houses men who are former addicts and alcoholics and who follow a strict program of recovery.
The permit is...
Hearing aids > Next Step Foundation files federal lawshuit against Stowe Township - Cites discrimination against recovering alcoholics and addicts
7 Keys to Turning Cold Calls Into Warm Calls
Let's face it when it comes to cold calling many of us fear being rejected.
What if I was to tell you I have come up with 7 keys to turning your cold calls into warm calls?
Would you believe me?Try these 7 cold calling ideas for yourself and see just how easy making a cold call
can really be.1.
Change Your Mental Objective Before You Make Your CallWhen making a cold call the traditional way, your main objective is usually to try and get the appointment or make the sale. The main problem with that is when you do make the call it is quite clear to the person on the other end of the phone that this is your goal and they usually think of an excuse to get you off the phone before they have a chance to hear what you have to say.To turn your cold calls into warm calls you need to change your objective to creating a feeling of trust with the person you are calling.
It is important to remember that the person you are calling needs to feel that you...
Hearing aids > 7 Keys to Turning Cold Calls Into Warm Calls
Nation?s Top Counterterrroism Expert Recalls A Similar Hostage Experience In The Wake of Bloody Russian Grade School Hostage Drama - Elsa Lee Warns School Officials and Parents to ?don?t get caught with your pants down.?
Los Angeles, CA (ContentDesk) September 4, 2004 -- "It could happen at any elementary school here in America,"
warns Counterterrorism Expert Elsa Lee, CEO, Advantage SCI, El Segundo, CA. Lee is referring to the bloody hostage drama in Beslan, Russia, where scores of bodies were found today (Friday) in a Russian school gymnasium as a three-day showdown between Russian security forces and suspected Chechen militants erupted in a bloody climax.Reporters at the scene said they witnessed about 100 corpses in the burned-out school gym where hundreds of students, teachers and parents were held hostage for two days in a southern Russian school. Russian troops stormed the building as terrorists opened fire.After hearing about the terrorist school takeover and how children, parents and teachers were herded into the school as they gathered for a ceremony marking the first day of class and the attackers issuing demands to Russian authorities while threatening to kill the children, Lee recalled...
Hearing aids > Nation?s Top Counterterrroism Expert Recalls A Similar Hostage Experience In The Wake of Bloody Russian Grade School Hostage Drama - Elsa Lee Warns School Officials and Parents to ?don?t get caught with your pants down.?
Equinox Publishing To Release MADE IN INDONESIA by Warwick Purser
(ContentDesk) September 28, 2005 -- On Wednesday, September 28, 2005 Equinox Publishing will release the long-awaited book MADE IN INDONESIA: A Tribute to the Country's Craftspeople by creative entrepreneur Warwick Purser. MADE IN INDONESIA is a 160-page hardcover book with over 180 full color images by Rio Helmi, one of Asia's most celebrated photographers. More than 23 suppliers and their handcrafted products are featured in eight chapters ranging from metal to wood and natural fibers to stone.Any...
silk Hearing aids Equinox Publishing To Release MADE IN INDONESIA by Warwick Purser Euroscreen Extends Its Patent Estate for CCR5 Chemokine Receptor and AIDS
Hearing aids > Equinox Publishing To Release MADE IN INDONESIA by Warwick Purser
Emergency Generators
The disruption of power for substantial lengths of time can occur at any time due to hurricanes, earthquakes, fires, snowfall and other natural calamities. Having emergency backup power in such situations is not only essential for hospitals and commercial establishments but also in homes to run critical appliances like lights, refrigerators, heaters and medical equipment.
There are basically two types of generators that can be used in an emergency: portable and permanent standby generators....
Hearing aids > Emergency Generators
7 Ways to Find Cheap Contact Lenses
Have you ever bought contact lenses and wished that you could get them without spending so much money? If you have, you will be happy to know that there are a couple of ways to get cheap contact lenses without sacrificing quality or your prescription.
1- Most people tend to think that buying their contact lenses from the eye doctors' inventory is the most expensive way to get them. This isn't always the case; often times your doctor will have special pricing for a large supply of...
Hearing aids > 7 Ways to Find Cheap Contact Lenses
Amazing Airline Pilot Can Play Any Song After Hearing It On His Piano Without Any Musical Training
(ContentDesk) January 3, 2006 -- Richard Waterman, gifted musician and performer, has released 3 new CDs of some of the most beautiful piano music in the world. Completely self taught, Richard began playing the piano in 1974, and has been compared to Mozart in his ability to reproduce a song after hearing it. He is one of a very small elite group of people in the world that play only by ear - not bound by a page of notes, Richard can hear a song, and play it as it was played the first time...
Hearing aids hearing aid Euroscreen Extends Its Patent Estate for CCR5 Chemokine Receptor and AIDS
Hearing aids > Amazing Airline Pilot Can Play Any Song After Hearing It On His Piano Without Any Musical Training
Humitech Completes $3,000,000 Financing and Acquires Mine
Humitech International Group Inc, http://humitechgroup.com announced today the completion of a $3,000,000 financing with a private equity group in New York City - terms were not disclosed.The Company will use $2,000,000 to acquire a 1600 Acre 'mine' that provides the exclusive world wide source of the Humitech Humidity Control Mineral, located in the Mojave Desert (near Area 51) balance of the funds will be used for inventory. The unique mixture...
Hearing aids Euroscreen Extends Its Patent Estate for CCR5 Chemokine Receptor and AIDS hotels
Hearing aids > Humitech Completes $3,000,000 Financing and Acquires Mine
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